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Tapentadol and Oxycodone are two opioids based pain relief medicine. The medicine has the ability to conduct a dual mechanism of action on opioid agonist and norepinephrine reuptake inhibitor; there is a possibility for it’s off label use in chronic pain.

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Tapentadol vs Oxycodone

Tapentadol and Oxycodone are two opioids based pain relief medicine.

The medicine has the ability to conduct a dual mechanism of action on opioid agonist and norepinephrine reuptake inhibitor; there is a possibility for it’s off label use in chronic pain.

Tapentadol is a new molecular substance that is structural, similar to tramadol.

Tapentadol is a centrally-acting analgesic by a dual approach of action,

First, as an active agonist at the mu-opioid receptor second as an active norepinephrine reuptake inhibitor.

Two of the following actions are effective against pain relief. The medicines action reflects on the aspects of tramadol and morphine substances.

Their ability to control pain is more comparing than the other hydrocodone and Oxycodone.

The dual-action mode of this drug provides analgesia at a similar level but in a more powerful and narcotic analgesics hydrocodone, meperidine and Oxycodone with other usual side effects.

In various pain care setting a survey showed that the Tapentadol relives severe to moderate pain effectively.

In the other hand, recent reports show that gastrointestinal related adverse events were very low, and lesser treatments were discontinued equivalent dosage of Oxycodone.

The combination of these reduced treatment discontinuation rates and Tapentadol efficacy for the relief of moderate to severe nociceptive

and neuropathic pain may offer an improvement in pain therapy by increasing patient compliance with their treatment regimen.

Nucynta ER || The Most Effective Pain Relief & Recreational Medication


The Nucynta ER is a usable medical drug; it’s from the Tapentadol group. This medicine is used for pain relief.

Patients with chronic pain and stress can relax with this medication.

The Tapentadol is known as an opioid pain reliever. It can manipulate hormones in our brain to decrease the pain for getting relieved.

Tapentadol is also very useful in case of nerve pain release.

Doctors recommend this remedy according to the patient’s condition and potential side effects.

Nucynta can also be taken for recreational purposes; it can provide massive blow with your mind.

People who love psychedelic experiences it’s a must-try medication for them.

The Tapentadol is a very potent drug with instant effects.

As a recreational user, you must decide about your current condition before consuming the drug.

Don’t worry; the drug is not entirely harmful unless you have any severe allergies and internal organ illnesses such as kidney and liver heart-related diseases.

So, know about your situation and then use it for recreational purpose. Mental and spiritual relaxation is essential in our mechanical work-based busy life.



Nucynta (C14H23NO) is a Tapentadol group drug; this drug stimulates our brain’s pain receptors and provides instant relief from chronic pain.

Doctors usually prescribe Nucynta for opioid medication.

Nucynta can be used for recreational consumption in our spare time. Tapentadol is known as a safe drug,

so people from young and old age can have it.

The medicine has a potent chemical formation of acting very quickly after usage.

Nucynta comes with a molar mass of 221.339 g/mol, and it has the elimination halftime of 4-6 hours (approximately).

Nucynta has different variants according to its strength, such as 50, 100, 150, 200 & 250 mg.

This fast-working drug is very effective against pain caused by diabetic peripheral neuropathy AKA (DPN).

Currently, there would be no available treatment for this medical condition unless the Tapentadol based opioid medication Nucynta.

Doctors prescribe this drug around the clock for the patient’s comfort.

The Collegium Pharmaceuticals currently owns the rights of Nucynta, which they acquired from Assertion Therapeutics, Inc.


Nucynta 50 mg

Nucynta 50 mg is a lethal dosage of the Tapentadol based opioid medicine. This small dosage is given to patients with primary stages of pain three times for a day.

Three times a day dosage of the 50 mg can block your pain if you have any.

In the case of recreational users, the 50 mg variant will offer a smooth psychedelic experience.


Nucynta Side Effects

Nucynta has side effects just like any other usual drugs, but you have to understand normal dosage won’t show any side effects.

Patients with a partial seizure should consider consulting with their physicians before taking this medication.

Regular users don’t have enough chances of side effects with lethal dosage. The medicine mixes with our blood and uses the cerebral spinal fluid to reach our brain.

Its first job is to block the sensitive pain generator system in our brain.

During this process, the users experience a massive chemical effect of cerebral hormones in the brain.

At the peak moment, you can feel your head-blowing and increased level of creativity.

This drug can instantly block your motor senses; taking precautions is highly recommended before taking the medication for refreshment.

Older people who have respiratory severe or coronary problems should never consider taking this medicine.

In rare cases, if you are having sleeping or anxiety problems, muscle aches and sudden behavior changes contact with your pharmacist or get a doctor.

Nucynta vs Oxycodone

Pain is a common problem in contemporary health care. A range of opioid analgesics is used to treat pain.

Tapentadol is increasingly used as it is believed to have increased analgesics efficacy and less adverse effects.

Nucynta and Oxycodone has some differences for their chemical effects and limitation,

Nucynta (Tapentadol) is an opioid, or narcotic, analgesic (painkiller). It is available in brand-name as both an immediate-release and extended-release pill.

The extended-release tablet is named as Nucynta ER. The primary dose is 50 mg to 100 mg every four to six hours as needed for pain.

Your doctor may alter the dose, and the maximum dose is 600 mg per day.

Oxycodone also has a similar formula like other opioid based formulas (and Oxycodone IR, mainly used for immediate-release) and prepared with the same brand-name form as Oxycontin—an instant-release tablet.

The dosage alters, but a standard dose for immediate-release oxycodone tablets is 5 to 15 mg each four to six hours as required for pain.


Tapentadol Side Effects

Tapentadol has side effects on medical misuse and abuse. The drug is highly addictive; using it for recreational use can lead to massive abuse.

Using the drug for occasional uses can’t lead into and the wrong conclusion.


  • Agitation,
  • Hallucinations,
  • Fever,
  • Sweating,
  • Fast heart rate,
  • Shivering,
  • Twitching,
  • Vomiting,
  • Muscle stiffness,
  • Diarrhoea,
  • Loss of coordination,
  • Nausea


Additional information


60 pills, 120 pills, 240 pills


50 mg, 100 mg

1 review for Tapentadol

  1. 5 out of 5

    Peter Canfield

    good product quality and excellent customer service.

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